PKA C alpha Rabbit Polyclonal Antibody

PKA C alpha Rabbit Polyclonal Antibody

• Description: The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.
• Product Name Alternative: cAMP dependent protein kinase beta catalytic subunit antibody cAMP dependent protein kinase alpha catalytic subunit antibody cAMP dependent protein kinase catalytic subunit alpha antibody cAMP dependent protein kinase catalytic subunit beta antibody PKA C alpha antibody PKA C beta antibody PKACA antibody PKACB antibody PRKACA antibody PRKACB antibody Protein kinase cAMP dependent catalytic alpha antibody Protein kinase cAMP dependent catalytic beta antibody
• Abbreviation: PKA C-alpha, PRKACA, PKACA
• CAS Number: 9007-83-4
• Swiss Prot: P17612 Human, P05132 Mouse, P27791 Rat
• Cellular Locus: Mitochondrion. Nucleus.Plasma membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human PKA C alpha aa 172-338.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: IF-Cell, IHC-P, FC
• Positive Control: A431, PC-3M, rat brain tissue, human kidney tissue, mouse testis tissue.
• Concentration: 1 mg/mL
• Dilution: IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 40.5 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No