AMACR Rabbit Polyclonal Antibody

AMACR Rabbit Polyclonal Antibody

• Description: P504S, also known as AMACR (α-methylacyl-CoA racemase), 2-methylacyl-CoA racemase or RACE, is an enzyme belonging to the caiB/baiF CoA-transferase family. Localizing to the peroxisome and mitochondrion, P504S plays a role in the metabolism of branched-chain fatty acids and bile acid intermediates. More specifically, P504S catalyzes the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers which can then be degraded by peroxisomal β-oxidation. Mutations in the gene encoding P504S can lead to AMACR deficiency, a disease characterized by increased concentrations of pristanic acid that is associated with adult onset sensory motor neuropathy, and/or CBAS4 (congenital bile acid synthesis defect type 4), a disorder characterized by intrahepatic cholestasis, absence of cholic acid from bile, neonatal jaundice and bile duct deficiency. In addition, P504S is overexpressed in prostate cancer and is believed to be functionally important for prostate cancer cell growth.
• Product Name Alternative: 2 arylpropionyl CoA epimerase antibody 2 methylacyl CoA racemase antibody 2-methylacyl-CoA racemase antibody Alpha methylacyl CoA racemase antibody Alpha methylacyl Coenzyme A racemase antibody Alpha methylacyl-CoA racemase deficiency, included antibody Alpha-methylacyl-CoA racemase antibody Amacr antibody AMACR deficiency, included antibody AMACR_HUMAN antibody CBAS4 antibody Da1-8 antibody EC 5.1.99.4 antibody Macr1 antibody Methylacyl CoA racemase alpha antibody RACE antibody RM antibody
• Abbreviation: AMACR
• CAS Number: 9007-83-4
• Swiss Prot: Q9UHK6 Human, O09174 Mouse
• Cellular Locus: Mitochondrion. Peroxisome.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within Human AMACR aa 1-382 / 382.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Human kidney tissue, mouse liver tissue lysate, Siha, SW480, HepG2, human liver tissue, human colon cancer tissue, mouse colon tissue, PC-3M.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500;IF-Cell: 1:50-1:100;IHC-P: 1:50-1:1,000;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 42 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No