AMACR Mouse Monoclonal Antibody [6F5]

AMACR Mouse Monoclonal Antibody [6F5]

• Description: AMACR, is an enzyme that responsible for converting (2R)-methylacyl-CoA esters to their (2S)-methylacyl-CoA epimers and known substrates, including coenzyme A esters of pristanic acid (mostly derived from phytanic acid, a 3-methyl branched-chain fatty acid that is abundant in the diet) and bile acids derived from cholesterol. Both decreased and increased levels of the enzyme in humans are linked with diseases. Reduction of the protein level or activity results in the accumulation of (2R)-methyl fatty acids such as bile acids which causes neurological symptoms. Increased levels of AMACR protein concentration and activity are associated with prostate cancer, and the enzyme is used widely as a biomarker (known in cancer literature as P504S) in biopsy tissues. Increased levels of AMACR are also associated with some breast, colon, and other cancers, but it is unclear exactly what the role of AMACR is in these cancers. This AMACR antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalinfixed, paraffin-embedded tissue sections using IHC test methods.
• Product Name Alternative: 2 arylpropionyl CoA epimerase antibody 2 methylacyl CoA racemase antibody 2-methylacyl-CoA racemase antibody Alpha methylacyl CoA racemase antibody Alpha methylacyl Coenzyme A racemase antibody Alpha methylacyl-CoA racemase deficiency, included antibody Alpha-methylacyl-CoA racemase antibody Amacr antibody AMACR deficiency, included antibody AMACR_HUMAN antibody CBAS4 antibody Da1-8 antibody EC 5.1.99.4 antibody Macr1 antibody Methylacyl CoA racemase alpha antibody RACE antibody RM antibody
• Abbreviation: AMACR
• CAS Number: 9007-83-4
• Swiss Prot: Q9UHK6 Human, O09174 Mouse, P70473 Rat
• Cellular Locus: Mitochondrion. Peroxisome.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human AMACR aa 1-382 / 382.
• Isotype: IgG1
• Clone: 6F5
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB
• Positive Control: SiHa cell lysate, human liver tissue lysate, human kidney tissue, human liver tissue, human prostate carcinoma tissue, human colon carcinoma tissue, mouse kidney tissue, rat kidney tissue, A549.
• Concentration: 2 mg/mL
• Dilution: WB: 1:500-1:2,000
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 42 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No