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CD71 Rabbit Polyclonal Antibody

CAT: 0992-ER1706-35Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1706-35Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.
CAS Number
9007-83-4
Product Name Alternative
CD 71 antibody CD71 antibody CD71 antigen antibody IMD46 antibody OTTHUMP00000208523 antibody OTTHUMP00000208524 antibody OTTHUMP00000208525 antibody p90 antibody sTfR antibody T9 antibody TFR 1 antibody TfR antibody TfR1 antibody TFR1_HUMAN antibody TFRC antibody TR antibody Transferrin receptor (p90 CD71) antibody Transferrin receptor protein 1, serum form antibody Trfr antibody
Abbreviation
TR, TfR, TfR1, Trfr, sTfR, TFRC
Swiss Prot
P02786 Human
Cellular Locus
Secreted and Cell membrane. Melanosome.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human CD71 aa 463-750 / 760.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IHC-P
Positive Control
Human lung cancer tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
IHC-P: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 85 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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