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CD73 Rabbit Polyclonal Antibody

CAT: 0992-R1107-6Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1107-6Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.
CAS Number
9007-83-4
Product Name Alternative
5' NT antibody 5' nucleotidase (CD73) antibody 5' nucleotidase precursor antibody 5' nucleotidase, ecto antibody 5' nucleotidase, ecto (CD73) antibody 5'-NT antibody 5'-nucleotidase antibody 5NTD_HUMAN antibody CD73 antibody CD73 antigen antibody E5NT antibody Ecto 5' nucleotidase antibody Ecto-5'-nucleotidase antibody eN antibody eNT antibody NT antibody NT5 antibody NT5E antibody NTE antibody Purine 5 Prime Nucleotidase antibody
Abbreviation
5'-NT
Swiss Prot
P21589 Human, Q61503 Mouse
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within Human CD73 aa 231-280 / 574.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Hela, A549, Jurkat, HT-29, HepG2.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 63kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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