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DGCR8 rabbit pAb

CAT: 0855-ES16953-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16953-01Size:50 µL
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Background
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Description
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
Product Name Alternative
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
UniProt
Q8WYQ5
Swiss Prot
Q8WYQ5
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human DGCR8 AA range: 467-517
Target
DGCR8
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleolus . Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC) . Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994) .
Other Product Names
Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
Gene ID (Human)
54487

UniProtKB · Q8WYQ5

Microprocessor complex subunit DGCR8

DGCR8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8WYQ5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DGCR8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R8G1, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

HemeIronMetal-binding

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Cellular component

Nucleus

Domain

Repeat

Molecular function

RNA-binding

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