Anti-Hu CLEC2 APC

• Description:

  CLEC2 (C-type lectin-like receptor 2) functions as a platelet receptor for the lymphatic endothelial marker, PDPN, and mediates platelet activation. Besides platelets, it can be found on myeloid cells and NK cells. CLEC2 functions also as an attachment factor for HIV-1 and facilitates its capture by platelets. Platelet-aggregating snake venom protein rhodocytin also binds to CLEC2.

• Certification:

  RUO

• Immunogen:

  A recombinant extracellular domain of human CLEC2 (amino acids 68-229)

• Target Antigen:

  CLEC2

• Clone:

  AYP1

• Applications:

  FC (QC tested)

• Format:

  APC

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Gitz E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Nash GB, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P, Watson SP: CLEC-2 expression is maintained on activated platelets and on platelet microparticles. Blood 2014 Oct 2;124 (14) :2262-70, URL: https://pubmed.ncbi.nlm.nih.gov/25150298/, *Sung PS, Huang TF, Hsieh SL: Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. Nat Commun. 2019 Jun 3;10 (1) :2402 , URL: https://pubmed.ncbi.nlm.nih.gov/31160588/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The mouse monoclonal antibody AYP1 recognizes an epitope within the extracellular part of CLEC2, a transmembrane glycoprotein expressed on activated plateles and on platelet microparticles.

• Applications Notes:

  6

• Species:

  Human

• CAS Number:

  9007-83-4

• Isotype:

  Mouse IgG1 kappa