Anti-Hu CLEC2 Purified

Anti-Hu CLEC2 Purified

• Background: CLEC2 (C-type lectin-like receptor 2) functions as a platelet receptor for the lymphatic endothelial marker, PDPN, and mediates platelet activation. Besides platelets, it can be found on myeloid cells and NK cells. CLEC2 functions also as an attachment factor for HIV-1 and facilitates its capture by platelets. Platelet-aggregating snake venom protein rhodocytin also binds to CLEC2.
• Specifications: The mouse monoclonal antibody AYP1 recognizes an epitope within the extracellular part of CLEC2, a transmembrane glycoprotein expressed on activated plateles and on platelet microparticles.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: A recombinant extracellular domain of human CLEC2 (amino acids 68-229)
• Target Antigen: CLEC2
• Isotype: Igg1 κ
• Clone: AYP1
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
• Validated Applications: ICC, FC, IP
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Gitz E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Nash GB, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P, Watson SP: CLEC-2 expression is maintained on activated platelets and on platelet microparticles. Blood 2014 Oct 2124(14):2262-70, URL: https://pubmed.ncbi.nlm.nih.gov/25150298/,*Sung PS, Huang TF, Hsieh SL: Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. Nat Commun. 2019 Jun 310(1):2402 , URL: https://pubmed.ncbi.nlm.nih.gov/31160588/,
• Storage Conditions: Store at 2-8°C. Do not freeze.