OP-1074

CAT: 0804-HY-125263-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125263-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2) -stimulated transcription with IC50 values of 1.6 and 3.2 nM, respectively.
CAS Number
[1443752-76-8]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/op-1074.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C=C1)C(C)=C(C3=CC=C(O)C=C3)[C@H](C4=CC=C(OCCN5CC[C@@H](C)C5)C=C4)O2
Molecular Formula
C29H31NO4
Molecular Weight
457.56
References & Citations
[1]Fanning SW, et al. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.Nat Commun. 2018 Jun 18;9 (1) :2368.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ

Related Products

CatalogName
HY-13846BM-1074
HY-170817SMI-1074
HY-P10345OP-145
HY-136978-01OP-5244
HY-125839OP-3633
HY-106110OP-2507
HY-136978A-01OP-5244 (sodium)
HY-171113CP-LC-1074
HY-108573-01P-1075
HY-167092SD-1077

Alternative Products

CatalogName
MBS5767243OP-1074
OR1075503(R) -OP-1074
A4198-25BM-1074
MF-0113807-01SMI-1074
A12743-25BM-1074 25mg
A12743-10BM-1074 10mg
A12743-100BM-1074 100mg
MF-0111377-01CP-LC-1074
A12743-50BM-1074 50mg
A12743-200BM-1074 200mg

Popular Products