MC-SN38

MC-SN38

• CAS Number: 1473403-87-0
• UNSPSC Description: MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mc-sn38.html
• Smiles: O=C(CCCCCN(C1=O)C(C=C1)=O)O[C@@](C(C=C(C2=NC3=CC=C4O)N5CC2=C(C3=C4)CC)=C6C5=O)(C(OC6)=O)CC
• Molecular Weight: 585.60
• References & Citations: [1]Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.|[2]Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.
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