Mc-VC-PAB-SN38

Mc-VC-PAB-SN38

• CAS Number: 1801838-28-7
• UNSPSC Description: Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mc-vc-pab-sn38.html
• Purity: 96.38
• Solubility: DMSO : 28.57 mg/mL (ultrasonic)
• Smiles: O=C1OCC(C2=O)=C(C=C(N2CC3=C(CC)C4=C5)C3=NC4=CC=C5O)[C@]1(CC)OC(OCC6=CC=C(C=C6)NC([C@@H](NC([C@@H](NC(CCCCCN7C(C=CC7=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O
• Molecular Weight: 991.05
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: No Development Reported