CDK8-IN-13

CDK8-IN-13

• CAS Number: 918523-75-8
• UNSPSC Description: CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC50 value of 51.9 nM. CDK8-IN-13 induces Apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity[1].
• Target Antigen: Apoptosis; CDK
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk8-in-13.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=CC(C2=CN=C3NC=CC3=C2)=C1)N
• Molecular Weight: 237.26
• References & Citations: [1]Zhang XX, et al. Discovery of a novel oral type Ⅰ CDK8 inhibitor against acute myeloid leukemia. Eur J Med Chem. 2023 May 5;251:115214.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported