Memantine-d6 (hydrochloride)-6

Memantine-d6 (hydrochloride)-6

• CAS Number: 9007-83-4
• UNSPSC Description: Memantine-d6 (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively[1].
• Target Antigen: Autophagy; Cytochrome P450; iGluR
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Neurological Disease
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: [2H]C([2H])([2H])[C@@](C[C@@](N)(C[C@@H]1C2)C3)(C1)C[C@@]32C([2H])([2H])[2H].Cl
• Molecular Weight: 221.80
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34.|[3]Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36.|[4]Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported