DX600 (TFA)

CAT: 0804-HY-P2222A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P2222A-01Size:1 mg
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Description
DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity[1][2][3].
UNSPSC
12352209
Target
Angiotensin-converting Enzyme (ACE)
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dx600-tfa-1.html
Purity
99.20
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Ac-GDYSHCSPLRYYPWWKCTYPDPEGGG-NH2(Disulfidebridge:Cys6-Cys17)(TFA)]
Molecular Formula
C141H185N35O40S2.xC2HF3O2
Molecular Weight
3074.33 (free acid)
References & Citations
[1]Liao K, et al. Development of an enzymatic assay for the detection of neutralizing antibodies against therapeutic angiotensin-converting enzyme 2 (ACE2) .J Immunol Methods. 2013 Mar 29;389 (1-2) :52-60. |[2]Yousif MH, et al. Characterization of Angiotensin- (1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes. Pharmacol Res. 2012 Sep;66 (3) :269-75. |[3]Svilenov HL, et al. Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2. Commun Biol. 2023 Apr 8;6 (1) :386. |[4]Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33. |[5]Fraga-Silva RA, et al. ACE2 activation promotes antithrombotic activity. Mol Med. 2010 May-Jun;16 (5-6) :210-5.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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