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ω-Agatoxin IVA (TFA)

CAT: 0804-HY-P1080A-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1080A-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA TFA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels[1][2].
UNSPSC
12352209
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ω-agatoxin-iva-tfa.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[w-AgatoxinIVA(TFAsalt)]
Molecular Formula
C217H360N68O60S10.C2HF3O2
Molecular Weight
5316.27
References & Citations
[1]M Kimura, et al. Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices. Neuroscience. 1995 Jun;66 (3) :609-15.|[2]T Teramoto, et al. A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons. Brain Res. 1997 May 9;756 (1-2) :225-30.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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