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ω-Agatoxin IVA

CAT: 0804-HY-P1080-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1080-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels[1][2].
CAS Number
145017-83-0
UNSPSC
12352209
Hazard Statement
H302-H312-H332
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ω-agatoxin-iva.html
Solubility
H2O
Smiles
[OMEGA-AgatoxinIVA]
Molecular Formula
C217H360N68O60S10
Molecular Weight
5202.25
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]T Teramoto, et al. A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons. Brain Res. 1997 May 9;756 (1-2) :225-30.|[2]M Kimura, et al. Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices. Neuroscience. 1995 Jun;66 (3) :609-15.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
P/Q-type calcium channel

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