ω-agatoxin-IVA

CAT: 0466-11AGA001-00100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0466-11AGA001-00100Size:0.1 mg
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Description
ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1) . It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials) . This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
CAS Number
145017-83-0
Specifications
Blocker of P/Q-type calcium channel (Cav2.1)
Target
Ca channels
Sequence
KKKCIAKDYGRCKWGGTPCCRGRGCICSIMGTNCECKPRLIMEGLGLA
Peptide Number
11AGA001
Disulfide Bonds
Cys4-Cys20; Cys12-Cys25; Cys19-Cys36; Cys27-Cys34
N Terminal Sequence
H
C Terminal Sequence
OH

Alternative Products

CatalogName
4030173.1000Ω-Agatoxin IVa
MDP0287Biotinyl-ω-Agatoxin IVA
H-1544.1000o-Agatoxin IVa
BIBA1037Omega-Agatoxin IVa
C8722-.1ω-Agatoxin IVA TFA
HY-P1080A-01ω-Agatoxin IVA (TFA)
3402-sBiotinyl-ω-Agatoxin IVA
MBS5817701omega-Agatoxin IVA TFA
sc-200190ω-Agatoxin TK
MBS5779348Agatoxin-489

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