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10-Methoxy-canthin-6-one

CAT: 0804-HY-169067-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169067-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML) [1][2].
CAS Number
86293-40-5
Product Name Alternative
Mtx-C
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis; p38 MAPK
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/10-methoxy-canthin-6-one.html
Purity
98.71
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=CC2=NC=CC3=C2N1C4=CC=C(OC)C=C34
Molecular Formula
C15H10N2O2
Molecular Weight
250.25
References & Citations
[1]Torquato HFV, et al. DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells. ACS Omega. 2024 Aug 22;9 (35) :37343-37354.|[2]Li N, et al. Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives. Molecules. 2019 Apr 19;24 (8) :1553.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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