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10-Methoxy-canthin-6-one

CAT: 0931-T200611-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200611-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
86293-40-5
Target
P38 MAPK
Related Pathways
MAPK
Bioactivity
10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC) . Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.
Smiles
O=C1C=CC2=NC=CC=3C4=CC(OC)=CC=C4N1C23
Molecular Formula
C15H10N2O2
Molecular Weight
250.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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