10-Methoxy-canthin-6-one

• Target:

  P38 MAPK

• Related Pathways:

  MAPK

• Bioactivity:

  10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC) . Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.

• Smiles:

  O=C1C=CC2=NC=CC=3C4=CC (OC) =CC=C4N1C23

• Molecular Formula:

  C15H10N2O2

• Molecular Weight:

  250.25

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  86293-40-5