FXR/CES2 modulator 1

• Description:

  FXR/CES2 modulator 1 (compound LE-77) is a doul modulator that activates FXR and inhibits CES2. FXR/CES2 modulator 1 effectively mitigates the intestinal toxicity of irinotecan[1].

• UNSPSC:

  12352005

• Target:

  FXR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/fxr-ces2-modulator-1.html

• Smiles:

  O=C (O) COC1=CC=C (C2=CC=C (OCC3=C (C4CC4) ON=C3C5=C (Cl) C=CC=C5Cl) C=C2) C=C1

• Molecular Formula:

  C27H21Cl2NO5

• Molecular Weight:

  510.37

• References & Citations:

  [1]Zhijun Cao, et al. Discovery of the FXR/CES2 dual modulator LE-77 for the treatment of irinotecan-induced delayed diarrhea. Bioorg Chem. 2024 Sep 29:153:107852.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3004676-87-0