CES2-IN-1

• Description :

  CES2-IN-1 (Compound 24) is a reversible and selective CES2 inhibitor (IC50: 6.72 μM for human CES2) . CES2-IN-1 reduces the level of CES2 in living cells. CES2-IN-1 is effective against Irinotecan (HY-16562) -induced delayed diarrhea and DSS-induced ulcerative colitis[1].

• CAS Number :

  [2994634-52-3]

• UNSPSC :

  12352005

• Target :

  Carboxylesterase (CES)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hces2-in-1.html

• Purity :

  98.18

• Solubility :

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  ClC1=CC=CC2=C1N=C(C=C2)NC3=NC4=CC=CC=C4N3

• Molecular Formula :

  C16H11ClN4

• Molecular Weight :

  294.74

• References & Citations :

  [1]Cao Z, et al. Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis. Biochem Pharmacol. 2023 Sep;215:115742.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CES2