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CES2-IN-1

CAT: 0804-HY-155181-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155181-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CES2-IN-1 (Compound 24) is a reversible and selective CES2 inhibitor (IC50: 6.72 μM for human CES2). CES2-IN-1 reduces the level of CES2 in living cells. CES2-IN-1 is effective against Irinotecan -induced delayed diarrhea and DSS-induced ulcerative colitis[1].
CAS Number
2994634-52-3
UNSPSC
12352005
Target
Carboxylesterase (CES)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hces2-in-1.html
Purity
98.18
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC=CC2=C1N=C(C=C2)NC3=NC4=CC=CC=C4N3
Molecular Formula
C16H11ClN4
Molecular Weight
294.74
References & Citations
[1]Cao Z, et al. Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis. Biochem Pharmacol. 2023 Sep;215:115742.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CES2

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