LPAR1 antagonist 1

CAT:

804-HY-162267

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UNSPSC Description: LPAR1 antagonist 1 (compound 18) is a potent, oral active and selective LPAR1 antagonist with the IC50 of 3.3 nM. LPAR1 antagonist 1 can be used for study of fibrosis[1].
Target Antigen: LPL Receptor
Type: Reference compound
Related Pathways: GPCR/G Protein
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/lpar1-antagonist-1.html
Solubility: 10 mM in DMSO
Smiles: CC(C1=CC=CC=C1C2(C(NC3=CC=C(C=C3OC)C)=O)CCN(C(CCC(O)=O)=O)CC2)C
Molecular Weight: 466.57
References & Citations: [1]Lescop C, et al. Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular Scaffold. J Med Chem. 2024 Feb 22;67(4):2379-2396.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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