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QKY-613

CAT: 0804-HY-159925Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159925Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QKY-613 is a prodrug that enhances immune surveillance by targeting nucleic acid modification pathways. QKY-613 promotes the selective incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, enhancing the phase separation potential of DNA, thereby increasing the activation of cGAS and strengthening host immune surveillance. In virus-infected mouse models, QKY-613 significantly reduced mortality in aged mice. QKY-613 holds promise for research on nucleic acid modification-based immune surveillance mechanisms[1].
CAS Number
2646682-38-2
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/qky-613.html
Smiles
O[C@H]1C[C@H](N(C=N2)C3=C2C(NC)=NC=N3)O[C@@H]1COP(OC4=CC=CC=C4)(N[C@H](C(OCC5=CC=CC=C5)=O)C)=O
Molecular Formula
C27H31N6O7P
Molecular Weight
582.54
References & Citations
[1]Wang N, et al. Host RNA N6-methyladenosine and incoming DNA N6-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance. Mol Ther. 2024 Dec 4;32 (12) :4418-4434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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