(E/Z) -MCB-613

• Description:

  (E/Z) -MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z) -MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z) -MCB-613 is a cytotoxic molecule that plays an important role in cancer[1].

• UNSPSC:

  12352005

• Target:

  Paraptosis; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-z-mcb-613.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1/C(CC(CC)C/C1=C\C2=CC=CN=C2)=C/C3=CC=CN=C3

• Molecular Formula:

  C20H20N2O

• Molecular Weight:

  304.39

• References & Citations:

  [1]Lei Wang, et al. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28 (2) :240-52.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [296792-62-6]