QKY-613

• Target :

  Others|||cGAS

• Related Pathways :

  Immunology/Inflammation|||Others

• Bioactivity :

  QKY-613 is a prodrug designed to enhance immune surveillance by targeting nucleic acid modification pathways. It selectively facilitates the incorporation of 6mdA (N6-methyl-deoxyadenosine) into viral DNA, boosting the DNA's phase separation potential and subsequently increasing cGAS activation levels to strengthen host immune surveillance. In mouse models of viral infection, QKY-613 significantly reduced mortality in aged mice. This compound holds promise for studying immune surveillance mechanisms based on nucleic acid modifications.

• Smiles :

  N(C)C1=C2C(N(C=N2)C3O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OCC5=CC=CC=C5)=O)C)=O)[C@@H](O)C3)=NC=N1

• Molecular Formula :

  C27H31N6O7P

• Molecular Weight :

  582.55

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2484713-92-8