Human Beta Nerve Growth Factor Recombinant Rabbit Monoclonal Antibody [PSH07-81] - BSA and Azide free (Detector)

CAT:

992-HA722904

Size:

100 µL

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Human Beta Nerve Growth Factor Recombinant Rabbit Monoclonal Antibody [PSH07-81] - BSA and Azide free (Detector)

Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable) (PubMed:20978020). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
Product Name Alternative: Beta nerve growth factor antibody Beta NGF antibody Beta-nerve growth factor antibody Beta-NGF antibody HSAN5 antibody MGC161426 antibody MGC161428 antibody Nerve growth factor (beta polypeptide) antibody Nerve growth factor antibody Nerve growth factor beta antibody Nerve growth factor beta polypeptide antibody Nerve growth factor beta subunit antibody NGF antibody NGF_HUMAN antibody NGFB antibody NID67 antibody
Abbreviation: Beta-nerve growth factor Beta-NGF NGF NGFB
CAS Number: 9000-83-3
Swiss Prot: P01138 Human
Cellular Locus: Secreted
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human Beta Nerve Growth Factor aa 19-241.
Isotype: IgG
Clone: PSH07-81
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Det)
Positive Control: Recombinant Human Beta Nerve Growth Factor protein.
Concentration: 1 mg/mL
Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH07-79] to Human Beta Nerve Growth Factor antibody (Capture) (HA722902) or Rabbit monoclonal [PSH07-80] to Human Beta Nerve Growth Factor antibody (Capture) (HA722903) and recombinant Human Human Beta Nerve Growth Factor protein as the standard. The reference range value is 10.3-2,500pg/ml.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

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Alternative Products

Cat	Name
90223-A	Human beta Nerve Growth Factor
90223-B	Human beta Nerve Growth Factor
MBS618811-02	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS613128-01	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS611950-02	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS618300-02	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS611950-01	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS618710-02	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS618300-01	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)
MBS613128-02	Nerve Growth Factor, beta (NGF, Beta Nerve Growth Factor, Beta Nerve Growth Factor Precursor, Beta NGF, HSAN5, Nerve Growth Factor beta, Nerve Growth Factor beta Polypeptide, Nerve Growth Factor beta Subunit, NGFB)