PROTAC BTK Degrader-8

PROTAC BTK Degrader-8

• UNSPSC Description: PROTAC BTK Degrader-8 (compound 3) is an effective PROTAC BTK degrader that can be coupled to an ADC antibody to form a PAC.
• Target Antigen: Btk; PROTAC-Linker Conjugates for PAC
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-btk-degrader-8.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(C=C(C=C1)C(N2CCC3(CC2)CCN(CC3)CCC4=CC=C(C=C4)C5=CC6=C(N5)N=CN=C6C7=CC(F)=CC(NC(C8=CC=C(C=C8F)C(C)(O)C)=O)=C7C)=O)N9CCC(N(C9=O)COP(O)(OP(O)(OCC%10=CC=C(C=C%10)NC([C@@H](NC([C@H](C(C)C)NC(CCOCCN%11C(C=CC%11=O)=O)=O)=O)CCCNC(N)=O)=O)=O)=O)=O
• Molecular Weight: 1671.63
• References & Citations: [1]Zhang A, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates. Bioconjug Chem. 2024;35(2):140-146.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported