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DISC1 rabbit pAb

CAT: 0855-ES16941-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16941-01Size:50 µL
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Background
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t (1;11) (q42.1; q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Description
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t (1;11) (q42. 1;q14. 3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
UniProt
Q9NRI5
Swiss Prot
Q9NRI5
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human DISC1 AA range: 423-473
Target
DISC1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton . Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell junction, synapse, postsynaptic density . Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity) . Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198, PubMed:15797709) . Colocalizes with PCNT at the centrosome (PubMed:18955030) . .
Gene ID (Human)
27185

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