Metesind (glucuronate)

• Description:

  Metesind glucuronate (AG 331) is an inhibitor for thymidylate synthase with Ki of 1.2 nM. Metesind glucuronate inhibits the DNA synthesis and thus inhibits the cell viability of cancer cells with IC50 of 0.4-0.9 μM[1].

• Product Name Alternative:

  AG 331

• UNSPSC:

  12352005

• Target:

  Thymidylate Synthase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/metesind-glucuronate.html

• Smiles:

  O=C[C@@H] ([C@H] ([C@@H] ([C@@H] (C (O) =O) O) O) O) O.O=S (N1CCOCC1) (C2=CC=C (CN (C3=CC=C4N=C (N) C5=CC=CC3=C54) C) C=C2) =O

• Molecular Formula:

  C29H34N4O10S

• Molecular Weight:

  630.67

• References & Citations:

  [1]Li WY, et al., High-performance liquid chromatographic method for the determination of a novel thymidylate synthase inhibitor, AG 331, in human serum. J Chromatogr B Biomed Appl. 1995 Nov 17;673 (2) :281-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  157182-23-5