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Metesind (glucuronate)

CAT: 0804-HY-19157Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19157Size:1 Each
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Description
Metesind glucuronate (AG 331) is an inhibitor for thymidylate synthase with Ki of 1.2 nM. Metesind glucuronate inhibits the DNA synthesis and thus inhibits the cell viability of cancer cells with IC50 of 0.4-0.9 μM[1].
CAS Number
157182-23-5
Product Name Alternative
AG 331
UNSPSC
12352005
Target
Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/metesind-glucuronate.html
Smiles
O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O.O=S(N1CCOCC1)(C2=CC=C(CN(C3=CC=C4N=C(N)C5=CC=CC3=C54)C)C=C2)=O
Molecular Formula
C29H34N4O10S
Molecular Weight
630.67
References & Citations
[1]Li WY, et al., High-performance liquid chromatographic method for the determination of a novel thymidylate synthase inhibitor, AG 331, in human serum. J Chromatogr B Biomed Appl. 1995 Nov 17;673 (2) :281-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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