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Trimetrexate (glucuronate) (Standard)

CAT: 0804-HY-103396RSize: 1 EachDry Ice: NoHazardous: No
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Description
Trimetrexate (glucuronate) (Standard) is the analytical standard of Trimetrexate (glucuronate) . This product is intended for research and analytical applications. Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia[1][2].
CAS Number
82952-64-5
Product Name Alternative
CI-898 (glucuronate) (Standard)
UNSPSC
12352005
Target
Antifolate; Bacterial; Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Cancer; Infection
Smiles
O=C[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O)O)O)O.NC1=NC(N)=C2C(C)=C(CNC3=CC(OC)=C(OC)C(OC)=C3)C=CC2=N1
Molecular Formula
C25H33N5O10
Molecular Weight
563.56
References & Citations
[1]R C Jackson, et al. Biochemical pharmacology of the lipophilic antifolate, trimetrexate. Adv Enzyme Regul. 1984;22:187-206.|[2]P J Harris, et al. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect. AIDS Patient Care STDS. 1996 Oct;10 (5) :280-1.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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