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Antiproliferative agent-57

CAT: 0804-HY-169100Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169100Size:1 Each
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Description
Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secretion of VEGF in SiHa cells under hypoxic conditions (IC50=0.68 μM) without inducing cytotoxicity. Antiproliferative agent-57 can modulate the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells to inhibit the expression of HIF-1α and VEGF in tumor tissues[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Akt; HIF/HIF Prolyl-Hydroxylase; mTOR; p38 MAPK; PI3K; VEGFR
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-57.html
Smiles
COC(C1=CC[C@@]2(C(O[C@](C)(/C=C/C=C(C)/C(OCC(NCC3=CN(C4=CC=C(Cl)C=C4)N=N3)=O)=O)[C@]5([H])CC2)=O)[C@]5(OC(C)=O)CC1)=O
Molecular Formula
C34H37ClN4O9
Molecular Weight
681.13
References & Citations
[1]Deng H, et al. Design, Synthesis, and Evaluation of Antitumor Activity in Pseudolaric acid B Azole Derivatives: Novel and potent Angiogenesis inhibitor via Regulation of the PI3K/AKT and MAPK Mediated HIF-1/VEGF Signaling Pathway[J]. European Journal of Medicinal Chemistry, 2024: 116813.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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