PEN (rat) (TFA)

• UNSPSC Description:

  PEN (rat) TFA, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].

• Target Antigen:

  G protein-coupled Bile Acid Receptor 1

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pen-rat-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N1[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)C)=O)=O)CC(C)C)=O)C(C)C)=O)CC(N)=O)=O)CCC(O)=O)=O)CCC3)=O)CCC2)=O)C(C)C)=O)CCC(O)=O)=O)CCC1)=O)=O)CC(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)C(C)C.OC(C(F)(F)F)=O.[x]

• Molecular Weight:

  2301.59 (free base)

• References & Citations:

  [1]Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.|[2]Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported