PEN (rat)

• UNSPSC Description:

  PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].

• Target Antigen:

  G protein-coupled Bile Acid Receptor 1

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pen-rat.html

• Purity:

  99.24

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H]3N(CCC3)C(CNC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@@H](N)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Weight:

  2301.59

• References & Citations:

  [1]Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.|[2]Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  569364-13-2