SIRT2/6-IN-1

SIRT2/6-IN-1

• CAS Number: 1214468-35-5
• UNSPSC Description: SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1].
• Target Antigen: Histone Demethylase; Sirtuin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/sirt2-6-in-1.html
• Purity: 98.44
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=S(C1=CC2=C(C=C1)NC(NC2=O)=O)(NC3=CC=C(C=C3)OC4=CC=CN=C4)=O
• Molecular Weight: 410.40
• References & Citations: [1]Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported