hCAI/II-IN-8

hCAI/II-IN-8

• CAS Number: 3036136-18-9
• UNSPSC Description: hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC50 = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). [1].[1].
• Target Antigen: Carbonic Anhydrase; Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/hcai-ii-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: CN(C)C1=CC=C(C(OC2=CC=C(/C=N/NC(C3=CN=CC=C3)=O)C=C2)=O)C=C1
• Molecular Weight: 388.42
• References & Citations: [1]Çakmak, R.et al. Synthesis of Novel Hydrazide–Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II. ACS Omega, 9(18), 20030–20041.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported