hCAI/II-IN-6

hCAI/II-IN-6

• CAS Number: 694466-00-7
• UNSPSC Description: hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy[1].
• Target Antigen: Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/hcai-ii-in-6.html
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(NC1=CC=C(S(=O)(N)=O)C=C1)CN2CCN(CC3=CC=CC=C3)CC2
• Molecular Weight: 388.48
• References & Citations: [1]Mishra CB, et al. Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. J Med Chem. 2017 Mar 23;60(6):2456-2469.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported