Imipramine (Standard)

• Description:

  Imipramine (Standard) is the analytical standard of Imipramine. This product is intended for research and analytical applications. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5].

• UNSPSC:

  12352100

• Target:

  Apoptosis; Autophagy; Reference Standards; Serotonin Transporter

• Related Pathways:

  Apoptosis; Autophagy; Neuronal Signaling; Others

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Smiles:

  CN (C) CCCN1C2=CC=CC=C2CCC3=CC=CC=C31

• Molecular Formula:

  C19H24N2

• Molecular Weight:

  280.42

• References & Citations:

  [1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52 (2) :281-292.|[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413 (2) :311-7. |[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13 (6) :338-47. |[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.|[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264 (4) :2195-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  50-49-7