Products for Research Use Only
RegisterLogin

Imipramine-d4

CAT: 0804-HY-B1490AS1-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1490AS1-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Imipramine-d4 is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].
CAS Number
96705-18-9
UNSPSC
12352005
Target
Apoptosis; Autophagy; Isotope-Labeled Compounds; Serotonin Transporter
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Neuronal Signaling; Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
CN(C)CCCN1C2=C([2H])C=C([2H])C=C2CCC3=CC([2H])=CC([2H])=C31
Molecular Formula
C19H20D4N2
Molecular Weight
284.43
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52 (2) :281-292.|[3]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413 (2) :311-7. |[4]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13 (6) :338-47. |[5]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.|[6]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264 (4) :2195-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B1490A-01Imipramine
HY-107956Imipramine (pamoate)
HY-B1490AR-01Imipramine (Standard)
HY-B1490AS-01Imipramine-d6
HY-B1490-01Imipramine (hydrochloride)
HY-142122-01Imipramine N-oxide
HY-B1490S1Imipramine-d3 (hydrochloride)
HY-B1490R-01Imipramine (hydrochloride) (Standard)
HY-120896BImipramine Blue (chloride)
HY-132329S-012-Hydroxy imipramine-d6

Alternative Products

CatalogName
CS-T-56644Imipramine-2,4,6,8-d4 Hydrochloride
BA2970-50Imipramine
20-1519Imipramine antibody
CS-EL-00111Imipramine-d3
KAA07524-01Imipramine pamoate
I7250-02Imipramine discontinued
014783Imipramine-d6
MBS385478-01Imipramine Hydrochloride
MBS6125869-01Imipramine (PE)

Popular Products