Imipramine

• UNSPSC Description:

  Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5].

• Target Antigen:

  Apoptosis; Autophagy; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/imipramine.html

• Purity:

  98.78

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31

• Molecular Weight:

  280.415

• References & Citations:

  [1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292.|[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. |[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. |[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.|[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8.Nat Chem Biol. 2024 Feb 14.|Cell Commun Signal. 2023 May 25;21(1):123.|Inflammation. 2021 Jan 29.|J Agric Food Chem. 2024 Jul 11.|Pathogens. 2022 May 22;11(5):602.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  50-49-7