Imipramine

CAT: 0804-HY-B1490A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1490A-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5].
CAS Number
[50-49-7]
UNSPSC
12352005
Hazard Statement
H302, H336, H370, H400
Target
Apoptosis; Autophagy; Serotonin Transporter
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/imipramine.html
Purity
99.88
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
Molecular Formula
C19H24N2
Molecular Weight
280.42
Precautions
H302, H336, H370, H400
References & Citations
[1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52 (2) :281-292.|[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413 (2) :311-7. |[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13 (6) :338-47. |[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.|[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264 (4) :2195-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Int Immunopharmacol. 2025 Jan 6:147:113969.|Nat Chem Biol. 2024 Jul;20 (7) :857-866.|Cell Commun Signal. 2023 May 25;21 (1) :123.|Inflammation. 2021 Aug;44 (4) :1381-1395.|J Agric Food Chem. 2024 Jul 24;72 (29) :16177-16190.|Pathogens. 2022 May 22;11 (5) :602.

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