MLS-0053105

MLS-0053105

• CAS Number: 370572-36-4
• UNSPSC Description: MLS-0053105, a chloromaleimide, is a selective BFL-1 inhibitor with an IC50 of 0.4 µM for Bfl-1/F-Bid. MLS-0053105 shows over 10 times less potent inhibition of Bcl-W, Bcl-2, and Bcl-XL and no activity against Bcl-B and Mcl-1[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mls-0053105.html
• Smiles: O=C1C(Cl)=C(N2CCN(CC2)C)C(N1C3=CC=C(C(Cl)=C3)Cl)=O
• Molecular Weight: 374.65
• References & Citations: [1]Dayong Zhai, et al. High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1. J Biomol Screen. 2012 Mar;17(3):350-60.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported