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(6R) -ML753286

CAT: 0804-HY-116494A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116494A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(6R) -ML753286 is an isomer of ML753286. ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species[1].
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6r-ml753286.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
COC1=CC=C2C(NC3=C2C[C@]4(N([C@@H]3CC(C)C)C([C@@H](NC4=O)C)=O)[H])=C1
Molecular Formula
C20H25N3O3
Molecular Weight
355.43
References & Citations
[1]Liao M, et al. Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novelselective inhibitor of breast cancer resistance protein (BCRP) . Xenobiotica. 2018 May;48 (5) :467-477.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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