(S) -ML753286

• Description :

  (S) -ML753286 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.

• CAS Number :

  [1699720-85-8]

• UNSPSC :

  12352005

• Target :

  BCRP

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BCRP-IN-1.html

• Purity :

  99.39

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  COC1=CC=C2C(NC3=C2C[C@]4([H])N(C([C@H](C)NC4=O)=O)[C@H]3CC(C)C)=C1

• Molecular Formula :

  C20H25N3O3

• Molecular Weight :

  355.43

• References & Citations :

  [1]Li Y, et al. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2016 Jan 15;26 (2) :551-555.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported