endo CNTinh-03

• UNSPSC Description:

  Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model[1].

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/endo-cntinh-03.html

• Purity:

  99.96

• Solubility:

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(NC(C2C(C3CCC2C3)C(O)=O)=O)SC(C)=C1C4=CC=C(C)C=C4)OC

• Molecular Weight:

  427.51

• References & Citations:

  [1]Tradtrantip L, et al., Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion. Mol Pharmacol. 2009 Jan;75(1):134-42.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  345288-49-5