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Ziconotide (TFA)

CAT: 0804-HY-P0062ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P0062ASize:1 Each
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Description
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research[1].
Product Name Alternative
SNX-111 (TFA)
UNSPSC
12352209
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/ziconotide-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(N[C@]1([H])C(N[C@]2([H])C(N[C@@](C(NCC(N[C@@](C(N[C@@](C(N[C@](CCCNC(N)=N)([H])C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CSSC1)=O)=O)=O)=O)=O)([H])CSSC[C@@](NC([C@](NC([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N)CSSC2)=O)=O)=O)=O)=O)C)=O)([H])CCCCN)=O)([H])C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C3=O)=O)=O)=O)=O)=O)([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](N3)([H])CC4=CC=C(O)C=C4.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Molecular Formula
C116H179F21N36O46S7
Molecular Weight
3437.30
References & Citations
[1]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3 (1) :69-85.|[2]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55 (12) :9307-9327.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Launched
Isoform
N-type calcium channel

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