Ziconotide (TFA)

• Description :

  Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research[1].

• Product Name Alternative :

  SNX-111 (TFA)

• UNSPSC :

  12352209

• Target :

  Calcium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ziconotide-tfa.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N[C@H](C(N[C@]1([H])C(N[C@]2([H])C(N[C@@](C(NCC(N[C@@](C(N[C@@](C(N[C@](CCCNC(N)=N)([H])C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CSSC1)=O)=O)=O)=O)=O)([H])CSSC[C@@](NC([C@](NC([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N)CSSC2)=O)=O)=O)=O)=O)C)=O)([H])CCCCN)=O)([H])C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C3=O)=O)=O)=O)=O)=O)([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](N3)([H])CC4=CC=C(O)C=C4.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

• Molecular Formula :

  C116H179F21N36O46S7

• Molecular Weight :

  3437.30

• References & Citations :

  [1]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3 (1) :69-85.|[2]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55 (12) :9307-9327.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  Launched

• Isoform :

  N-type calcium channel