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Ziconotide (acetate)

CAT: 0804-HY-P0062B-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0062B-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research[1].
CAS Number
914454-03-8
Product Name Alternative
SNX-111 (acetate)
UNSPSC
12352209
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/ziconotide-acetate.html
Purity
99.29
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N[C@]1([H])C(N[C@]2([H])C(N[C@@](C(NCC(N[C@@](C(N[C@@](C(N[C@](CCCNC(N)=N)([H])C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CSSC1)=O)=O)=O)=O)=O)([H])CSSC[C@@](NC([C@](NC([C@@H](NC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](N)CSSC2)=O)=O)=O)=O)=O)C)=O)([H])CCCCN)=O)([H])C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C3=O)=O)=O)=O)=O)=O)([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](N3)([H])CC4=CC=C(O)C=C4.CC(O)=O.[x]
Molecular Formula
C102H172N36O32S7.xC2H4O2
Molecular Weight
2639.13 (free base)
References & Citations
[1]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3 (1) :69-85.|[2]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55 (12) :9307-9327.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Launched
Isoform
N-type calcium channel

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