(+) -Penbutolol

• Description:

  (+) -Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+) -Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].

• Product Name Alternative:

  (R) -Penbutolol; (+) -Isopenbutolol

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/__addition__-Penbutolol.html

• Purity:

  95.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@@H] (COC1=C (C=CC=C1) C2CCCC2) CNC (C) (C) C

• Molecular Formula:

  C18H29NO2

• Molecular Weight:

  291.43

• References & Citations:

  [1]Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca (2+) -overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118 (4) :865-70.|[2]Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271 (1) :1-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  β adrenergic receptor

• CAS Number:

  38363-41-6