(+)-Penbutolol

• UNSPSC Description:

  (+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/__addition__-Penbutolol.html

• Purity:

  95.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@@H](COC1=C(C=CC=C1)C2CCCC2)CNC(C)(C)C

• Molecular Weight:

  291.43

• References & Citations:

  [1]Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70.|[2]Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  38363-41-6