(-) -Penbutolol

• Description:

  (-) -Penbutolol ((S) -Penbutolol) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki values of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3[1][2].

• Product Name Alternative:

  (S) -Penbutolol; (-) -Isopenbutolol

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  5-HT Receptor; Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/minus-penbutolol.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H](COC1=CC=CC=C1C2CCCC2)CNC(C)(C)C

• Molecular Formula:

  C18H29NO2

• Molecular Weight:

  291.43

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-) penbutolol. J Pharmacol Exp Ther. 1993 May;265 (2) :707-12.|[2]M E Castro, et al. Affinity of (±) -Pindolol, (-) -Penbutolol, and (-) -Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762.|[3]Gartside SE, et al., Effects of (-) -tertatolol, (-) -penbutolol and (+/-) -pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127 (1) :145-52.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  38363-40-5