Taltobulin intermediate-9

• UNSPSC Description:

  Taltobulin intermediate-9 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

• Target Antigen:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/taltobulin-intermediate-9.html

• Purity:

  95.01

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)[C@@H](/C=C(C)/C(OCC)=O)N(C([C@H](C(C)(C)C)NC([C@H](N(C(OC(C)(C)C)=O)C)C(C)(C)C1=CC=CC=C1)=O)=O)C

• Molecular Weight:

  601.82

• References & Citations:

  [1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported