FAPI-74

FAPI-74

• CAS Number: 2374782-76-8
• UNSPSC Description: FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). FAPI-74 can be used for FAP-positive tumor research[1][2].
• Target Antigen: FAP
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fapi-74.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=NC(C=C2)=C1C=C2OCCCN(CC3)CCN3C(CN(CCN4CC(O)=O)CCN(CC4)CC(O)=O)=O)NCC(N(CCC5)[C@@H]5C#N)=O
• Molecular Weight: 735.83
• References & Citations: [1]Uwe Haberkorn, et al. Fap inhibitor. Patent, WO2019154886A1.|[2]Giesel FL, et al. FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients. J Nucl Med. 2021 Feb;62(2):201-207. |[3]Liu Y, et al. Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model. Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):871-880.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported