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Azide-PEG3-Tos

CAT: 0804-HY-140004-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140004-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
178685-33-1
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azide-peg3-tos.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[N-]=[N+]=NCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Molecular Formula
C13H19N3O5S
Molecular Weight
329.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Borchmann DE, et al. GRGDS-Functionalized Poly (lactide) -graft-poly (ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46 (11) :4426-4431.|[2]Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

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